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Platelet Inhibitors Reduce Rupture in a Mouse Model of Established Abdominal Aortic Aneurysm

2015; Lippincott Williams & Wilkins; Volume: 35; Issue: 9 Linguagem: Inglês

10.1161/atvbaha.115.305537

1524-4636

A. Phillip Owens, Todd L. Edwards, Silvio Antoniak, Julia E. Geddings, Eiman Jahangir, Wei‐Qi Wei, Joshua C. Denny, Yacine Boulaftali, Wolfgang Bergmeier, Alan Daugherty, Uchechukwu K.A. Sampson, Nigel Mackman,

Aortic Disease and Treatment Approaches

Rupture of abdominal aortic aneurysms causes a high morbidity and mortality in the elderly population. Platelet-rich thrombi form on the surface of aneurysms and may contribute to disease progression. In this study, we used a pharmacological approach to examine a role of platelets in established aneurysms induced by angiotensin II infusion into hypercholesterolemic mice.