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Characterizing the Effects of Caspofungin on Candida albicans , Candida parapsilosis , and Candida glabrata Isolates by Simultaneous Time-Kill and Postantifungal-Effect Experiments

2006; American Society for Microbiology; Volume: 50; Issue: 7 Linguagem: Inglês

10.1128/aac.00291-06

1098-6596

Cornelius J. Clancy, Hong Huang, Shaoji Cheng, Hartmut Derendorf, M. Hong Nguyen,

Plant-Microbe Interactions and Immunity

ABSTRACT We measured time-kills and postantifungal effects (PAFEs) of caspofungin against Candida albicans , C. parapsilosis , and C. glabrata isolates. One-hour exposure to caspofungin during PAFE experiments accounted for the majority of killing during time-kill experiments. Regrowth of all isolates was inhibited for at least 24 h following drug washout.