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Targeted Prostate Cancer Screening in BRCA1 and BRCA2 Mutation Carriers: Results from the Initial Screening Round of the IMPACT Study

2014; Elsevier BV; Volume: 66; Issue: 3 Linguagem: Inglês

10.1016/j.eururo.2014.01.003

1873-7560

Elizabeth Bancroft, Elizabeth Page, Elena Castro, Hans Lilja, Andrew J. Vickers, Daniel D. Sjoberg, Melissa Assel, Christopher S. Foster, Gillian Mitchell, Kate Drew, Lovise Mæhle, Karol Axcrona, D. Gareth Evans, Barbara Bulman, Diana Eccles, Donna McBride, Nicholas van As, Hans F. A. Vasen, Lambertus A. Kiemeney, Janneke Ringelberg, Cezary Cybulski, Dominika Wokołorczyk, Christina G. Selkirk, Peter J. Hulick, Anders Bojesen, Anne‐Bine Skytte, Jimmy Lam, Louise Taylor, Rogier A. Oldenburg, R.G.H.M. Cremers, Gerald W. Verhaegh, Wendy A. van Zelst-Stams, Jan C. Oosterwijk, Ignacio Blanco, Mònica Salinas, Jackie Cook, Derek J. Rosario, Saundra Buys, Tom Conner, Margreet G.E.M. Ausems, Kai‐ren Ong, Jonathan Hoffman, Susan M. Domchek, Jacquelyn Powers, Manuel R. Teixeira, Sofia Maia, William D. Foulkes, Nassim Taherian, Mariëlle Ruijs, Apollonia T. Helderman-van den Enden, Louise Izatt, Rosemarie Davidson, Muriel A. Adank, Lisa Walker, Rita K. Schmutzler, Kathy Tucker, Judy Kirk, Shirley Hodgson, Marion Harris, Fiona Douglas, Geoffrey J. Lindeman, Janez Žgajnar, Marc Tischkowitz, Virginia E. Clowes, Rachel Susman, Teresa Ramón y Cajal, Nicholas Patcher, Neus Gadea, Allan D. Spigelman, Theo van Os, Annelie Liljegren, Lucy Side, Carole Brewer, Angela F. Brady, Alan Donaldson, Vigdís Stefànsdóttir, Eitan Friedman, Rakefet Chen‐Shtoyerman, David J. Amor, Lucia Copáková, Julian Barwell, Veda N. Giri, Vedang Murthy, Nicola Nicolai, Soo‐Hwang Teo, Lynn Greenhalgh, Sara S. Strom, Alex Henderson, John McGrath, David Gallagher, Neil K. Aaronson, Audrey Ardern‐Jones, Chris Bangma, David Dearnaley, Philandra Costello, Jórunn E. Eyfjörd, Jeanette Rothwell, Alison Falconer, Henrik Grönberg, Freddie C. Hamdy, Oskar T. Johannsson, Vincent Khoo, Zsofia Kote‐Jarai, Jan Lubiński, Ulrika Axcrona, J Melia, Joanne McKinley, Anita Mitra, Clare Moynihan, Gad Rennert, Mohnish Suri, Penny Wilson, Emma Killick, Sue Moss, Rosalind A. Eeles,

Cancer Genomics and Diagnostics

Men with germline breast cancer 1, early onset (BRCA1) or breast cancer 2, early onset (BRCA2) gene mutations have a higher risk of developing prostate cancer (PCa) than noncarriers. IMPACT (Identification of Men with a genetic predisposition to ProstAte Cancer: Targeted screening in BRCA1/2 mutation carriers and controls) is an international consortium of 62 centres in 20 countries evaluating the use of targeted PCa screening in men with BRCA1/2 mutations.