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Reproducibility of cine displacement encoding with stimulated echoes (DENSE) cardiovascular magnetic resonance for measuring left ventricular strains, torsion, and synchrony in mice

2013; BioMed Central; Volume: 15; Issue: 1 Linguagem: Inglês

10.1186/1532-429x-15-71

1532-429X

Christopher M. Haggerty, Sage P. Kramer, Cassi M Binkley, David K. Powell, Andrea C Mattingly, Richard Charnigo, Frederick H. Epstein, Brandon K. Fornwalt,

Cardiovascular Function and Risk Factors

Advanced measures of cardiac function are increasingly important to clinical assessment due to their superior diagnostic and predictive capabilities. Cine DENSE cardiovascular magnetic resonance (CMR) is ideal for quantifying advanced measures of cardiac function based on its high spatial resolution and streamlined post-processing. While many studies have utilized cine DENSE in both humans and small-animal models, the inter-test and inter-observer reproducibility for quantification of advanced cardiac function in mice has not been evaluated. This represents a critical knowledge gap for both understanding the capabilities of this technique and for the design of future experiments. We hypothesized that cine DENSE CMR would show excellent inter-test and inter-observer reproducibility for advanced measures of left ventricular (LV) function in mice.