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DNA surface coating of calixarene-based nanoparticles: a sequence-dependent binding mechanism

2012; Royal Society of Chemistry; Volume: 48; Issue: 100 Linguagem: Inglês

10.1039/c2cc36859e

1364-548X

Vanessa Rullaud, Michael Siragusa, Alessandro Cumbo, Daniel Gygax, Patrick Shahgaldian,

Advanced biosensing and bioanalysis techniques

An amphiphilic calix[4]arene derivative bearing four guanidino moieties at the upper rim and four dodecyl chains at the lower rim was shown to form stable solid lipid nanoparticles (SLNs) in water. The study of the interactions of these cationic SLNs with DNA revealed a sequence-dependent groove binding mechanism.