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ARWEN: a program to detect tRNA genes in metazoan mitochondrial nucleotide sequences

2007; Oxford University Press; Volume: 24; Issue: 2 Linguagem: Inglês

10.1093/bioinformatics/btm573

1367-4811

Dean Laslett, Björn Canbäck,

RNA modifications and cancer

Mitochondrial genomes encode their own transfer RNAs (tRNAs). These are often degenerate in sequence and structure compared to tRNAs in their bacterial ancestors. This is one of the reasons why current tRNA gene predictor programs perform poorly identifying mitochondrial tRNA genes. As a consequence there is a need for a new program with the specific aim of predicting these tRNAs.In this study, we present the software ARWEN that identifies tRNA genes in metazoan mitochondrial nucleotide sequences. ARWEN detects close to 100% of previously annotated genes.An online version, software for download and test results are available at www.acgt.se/online.html