Portal de Periódicos da CAPES

MINCR is a MYC-induced lncRNA able to modulate MYC’s transcriptional network in Burkitt lymphoma cells

2015; National Academy of Sciences; Volume: 112; Issue: 38 Linguagem: Inglês

10.1073/pnas.1505753112

1091-6490

Gero Doose, Andrea Haake, Stephan Wolf, Cristina López, Sujitha Duggimpudi, Franziska Wojciech, Anke Bergmann, Arndt Borkhardt, Birgit Burkhardt, Alexander Claviez, Lora Dimitrova, Siegfried Haas, Jessica I. Hoell, Michael Hummel, Dennis Karsch, Wolfram Klapper, Karsten Kleo, Helene Kretzmer, Markus Kreuz, Ralf Küppers, Chris Lawerenz, Dido Lenze, Markus Loeffler, Luisa Mantovani‐Löffler, Peter Möller, German Ott, Julia Richter, Marius Rohde, Philip Rosenstiel, Andreas Rosenwald, Markus B. Schilhabel, Markus Schneider, Ingrid Scholz, Stephan Stilgenbauer, Hendrik G. Stunnenberg, Monika Szczepanowski, Lorenz Trümper, Marc A. Weniger, Steve Hoffmann, Reiner Siebert, Ingram Iaccarino, Gesine Richter, Reiner Siebert, Susanne Wagner, Andrea Haake, Julia Richter, Roland Eils, Chris Lawerenz, Sylwester Radomski, Ingrid Scholz, Christoph Borst, Birgit Burkhardt, Alexander Claviez, Martin Dreyling, Sonja Eberth, Hermann Einsele, Norbert Frickhofen, Siegfried Haas, Martin‐Leo Hansmann, Dennis Karsch, Michael Kneba, Jasmin Lisfeld, Luisa Mantovani‐Löffler, Marius Rohde, Christina Stadler, Peter Staib, Stephan Stilgenbauer, German Ott, Lorenz Trümper, Thorsen Zenz, Martin‐Leo Hansmann, Dieter Kube, Ralf Küppers, Marc A. Weniger, Siegfried Haas, Michael Hummel, Wolfram Klapper, Ulrike Kostezka, Dido Lenze, Peter Möller, Andreas Rosenwald, Monika Szczepanowski, Ole Ammerpohl, Sietse Aukema, Vera Binder, Arndt Borkhardt, Andrea Haake, Kebria Hezaveh, Jessica I. Hoell, Ellen Leich, Peter Lichter, Christina Lopez, Inga Nagel, Jordan Pischimariov, Bernhard Radlwimmer, Julia Richter, Philip Rosenstiel, Andreas Rosenwald, Markus B. Schilhabel, Stefan Schreiber, Inga Vater, Rabea Wagner, Reiner Siebert, Stephan Wolf, Hans Binder, Benedikt Brors, Gero Doose, Roland Eils, Roland Eils, Steve Hoffmann, Lydia Hopp, Helene Kretzmer, Markus Kreuz, Jan O. Korbel, David Langenberger, Markus Loeffler, Sylwester Radomski, Maciej Rosolowski, Matthias Schlesner, Peter F. Stadler, Stéphanie Sungalee,

RNA Research and Splicing

Significance Gains of the MYC gene are the most common imbalances in cancer and are associated with poor prognosis, particularly in B-cell lymphoma. Recent advances in DNA sequencing have revealed the existence of thousands of long noncoding RNAs (lncRNAs) with unknown functional relevance. We have here identified a MYC-regulated lncRNA that we named MYC-induced long noncoding RNA (MINCR) that has a strong correlation with MYC expression in cancer. We show that MINCR is functional and controls cell cycle progression by influencing the expression of MYC-regulated cell cycle genes. MINCR is, therefore, a novel player in MYC’s transcriptional network, with the potential to open new therapeutic windows in the fight against malignant lymphoma and, possibly, all cancers that rely on MYC expression.