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MHC class II–dependent basophil–CD4+ T cell interactions promote TH2 cytokine–dependent immunity

2009; Nature Portfolio; Volume: 10; Issue: 7 Linguagem: Inglês

10.1038/ni.1740

1529-2916

Jacqueline Perrigoue, Steven A. Saenz, Mark C. Siracusa, Eric J. Allenspach, Betsy C. Taylor, Paul Giacomin, Meera G. Nair, Yurong Du, Colby Zaph, Nico van Rooijen, Michael R. Comeau, Edward J. Pearce, Terri M. Laufer, David Artis,

Mast cells and histamine

Basophils act as effector cells in immunoglobulin E–mediated hypersensitivity responses. Artis, Nakanishi and Medzhitov and their colleagues report that basophils present antigen and induce T helper type 2 responses to helminths, allergens and immunoglobulin E immune complexes. Dendritic cells can prime naive CD4+ T cells; however, here we demonstrate that dendritic cell–mediated priming was insufficient for the development of T helper type 2 cell–dependent immunity. We identify basophils as a dominant cell population that coexpressed major histocompatibility complex class II and interleukin 4 message after helminth infection. Basophilia was promoted by thymic stromal lymphopoietin, and depletion of basophils impaired immunity to helminth infection. Basophils promoted antigen-specific CD4+ T cell proliferation and interleukin 4 production in vitro, and transfer of basophils augmented the population expansion of helminth-responsive CD4+ T cells in vivo. Collectively, our studies suggest that major histocompatibility complex class II–dependent interactions between basophils and CD4+ T cells promote T helper type 2 cytokine responses and immunity to helminth infection.