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Enantioselective synthesis of the methylenecyclopropane derivative related to hypoglycine, from malic acid

1992; Elsevier BV; Volume: 48; Issue: 46 Linguagem: Inglês

10.1016/s0040-4020(01)89048-7

1464-5416

Barbara Achmatowicz, Marek M. Kabat, J. W. Krajewski, Jerzy Wicha,

Fluorine in Organic Chemistry

Synthesis of (S)-methylenecyclopropaneacetic acid starting from L-(−)-malic acid, via (2S)-O-tert-butyldimethylsilyl-1,2-epoxybutan-4-ol and 1-O-tert-butyldiphenylsilyl-5-benzenesulfonyl-6-trimethylsilylhexane-1,3-diols as the key intermediates, is described.