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Emergence of KPC-Possessing Klebsiella pneumoniae in Brooklyn, New York: Epidemiology and Recommendations for Detection

2005; American Society for Microbiology; Volume: 49; Issue: 7 Linguagem: Inglês

10.1128/aac.49.7.3018-3020.2005

1098-6596

Simona Bratu, Mohamad Mooty, Satyen Nichani, David Landman, Carl R. Gullans, Barbara Pettinato, Usha Karumudi, Pooja Tolaney, John Quale,

Antibiotics Pharmacokinetics and Efficacy

Among 257 isolates of Klebsiella pneumoniae collected in Brooklyn, NY, 24% were found to possess bla(KPC). Clinical microbiology laboratories that used automated broth microdilution systems reported 15% of the KPC-possessing isolates as susceptible to imipenem. The imipenem MIC was found to be markedly affected by the inoculum. For accurate detection of KPC-possessing K. pneumoniae, particular attention should be paid to proper inoculum preparation for broth-based susceptibility methods. In addition, using ertapenem or meropenem for class reporting of carbapenem susceptibility will improve detection.