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BIBTEX RIS

Chemical constituents from Tabernaemontana catharinensis root bark: a brief NMR review of indole alkaloids and in vitro cytotoxicity

2008; Brazilian Chemical Society; Volume: 31; Issue: 1 Linguagem: Inglês

10.1590/s0100-40422008000100004

ISSN

1678-7064

Autores

Paulo Sérgio Pereira, Suzelei de Castro França, Paulo Vinicius Anderson de Oliveira, Camila Moniz de Souza Breves, Sarazete Izidia Vaz Pereira, Suely Vilela Sampaio, Auro Nomizo, Diones Aparecida Dias,

Tópico(s)

Berberine and alkaloids research

Resumo

This work describes the isolation and structural determination of pharmacological compounds present in the bark of roots of Tabernaemontana catharinensis (Apocynaceae). Among the 27 substances detected 12 were identified as terpenoid-indole alkaloids, 2 steroids and 13 pentacyclic triterpenes. Structures were outlined based on HMQC, COSY, DEPT, 13C, and ¹H NMR data and MS. Spectral data of indole alkaloids were reviewed. An in vitro screening of the extracts and isolated compounds was carried out. Compounds ibogamine (5), 3-oxo-coronaridine (9) and 12-methoxy-4-methylvoachalotine (MMV) demonstrated effective cytotoxicity towards SKBR-3 breast adenocarcinoma and C-8161 human melanoma tumor cell lines.

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