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Encapsulation of Myoglobin in PEGylated Polyion Complex Vesicles Made from a Pair of Oppositely Charged Block Ionomers: A Physiologically Available Oxygen Carrier

2007; Wiley; Volume: 46; Issue: 32 Linguagem: Inglês

10.1002/anie.200701776

1521-3773

Akihiro Kishimura, Aya Koide, Kensuke Osada, Yuichi Yamasaki, Kazunori Kataoka,

Luminescence and Fluorescent Materials

Angewandte Chemie International EditionVolume 46, Issue 32 p. 6085-6088 Communication Encapsulation of Myoglobin in PEGylated Polyion Complex Vesicles Made from a Pair of Oppositely Charged Block Ionomers: A Physiologically Available Oxygen Carrier† Akihiro Kishimura Dr., Akihiro Kishimura Dr. Department of Materials Engineering and Center for NanoBio Integration, Graduate School of Engineering, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8656, Japan, Fax: (+81) 3-5841-7139 http://www.bmw.t.u-tokyo.ac.jp/Search for more papers by this authorAya Koide, Aya Koide Department of Materials Engineering and Center for NanoBio Integration, Graduate School of Engineering, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8656, Japan, Fax: (+81) 3-5841-7139 http://www.bmw.t.u-tokyo.ac.jp/Search for more papers by this authorKensuke Osada Dr., Kensuke Osada Dr. Department of Materials Engineering and Center for NanoBio Integration, Graduate School of Engineering, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8656, Japan, Fax: (+81) 3-5841-7139 http://www.bmw.t.u-tokyo.ac.jp/Search for more papers by this authorYuichi Yamasaki Dr., Yuichi Yamasaki Dr. Department of Materials Engineering and Center for NanoBio Integration, Graduate School of Engineering, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8656, Japan, Fax: (+81) 3-5841-7139 http://www.bmw.t.u-tokyo.ac.jp/Search for more papers by this authorKazunori Kataoka Prof., Kazunori Kataoka Prof. kataoka@bmw.t.u-tokyo.ac.jp Department of Materials Engineering and Center for NanoBio Integration, Graduate School of Engineering, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8656, Japan, Fax: (+81) 3-5841-7139 http://www.bmw.t.u-tokyo.ac.jp/Search for more papers by this author Akihiro Kishimura Dr., Akihiro Kishimura Dr. Department of Materials Engineering and Center for NanoBio Integration, Graduate School of Engineering, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8656, Japan, Fax: (+81) 3-5841-7139 http://www.bmw.t.u-tokyo.ac.jp/Search for more papers by this authorAya Koide, Aya Koide Department of Materials Engineering and Center for NanoBio Integration, Graduate School of Engineering, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8656, Japan, Fax: (+81) 3-5841-7139 http://www.bmw.t.u-tokyo.ac.jp/Search for more papers by this authorKensuke Osada Dr., Kensuke Osada Dr. Department of Materials Engineering and Center for NanoBio Integration, Graduate School of Engineering, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8656, Japan, Fax: (+81) 3-5841-7139 http://www.bmw.t.u-tokyo.ac.jp/Search for more papers by this authorYuichi Yamasaki Dr., Yuichi Yamasaki Dr. Department of Materials Engineering and Center for NanoBio Integration, Graduate School of Engineering, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8656, Japan, Fax: (+81) 3-5841-7139 http://www.bmw.t.u-tokyo.ac.jp/Search for more papers by this authorKazunori Kataoka Prof., Kazunori Kataoka Prof. kataoka@bmw.t.u-tokyo.ac.jp Department of Materials Engineering and Center for NanoBio Integration, Graduate School of Engineering, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8656, Japan, Fax: (+81) 3-5841-7139 http://www.bmw.t.u-tokyo.ac.jp/Search for more papers by this author First published: 03 August 2007 https://doi.org/10.1002/anie.200701776Citations: 189 † This research was supported in part by a Grant-in-Aid for Scientific Research (No. 18810009) from the Ministry of Education, Culture, Sports, Science, and Technology (MEXT) of Japan, and by a Grant for 21st Century COE Program "Human-Friendly Materials Based on Chemistry" from MEXT. The authors express their appreciation to Dr. A. Hirano for preparation of the TRITC-Mb, and to Dr. D. Y. Furgeson for helpful comments on the preparation of the manuscript. PEG: polyethylene glycol. Read the full textAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinked InRedditWechat Abstract Take your PIC: Biologically active polyion complex vesicles (PICsomes) with encapsulated myoglobin (Mb) can be prepared by the self-assembly of a pair of oppositely charged block ionomers with polyethylene glycol (PEG) segments (see picture; metMb: metmyoglobin). The loaded Mb maintains reversible oxygenation even in the presence of trypsin. Citing Literature Supporting Information Supporting information for this article is available on the WWW under http://www.wiley-vch.de/contents/jc_2002/2007/z701776_s.pdf or from the author. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article. Volume46, Issue32August 13, 2007Pages 6085-6088 RelatedInformation