Portal de Periódicos da CAPES

Neuroimmunology (PP-012)

2010; Oxford University Press; Volume: 22; Issue: Suppl_1_Pt_1 Linguagem: Inglês

10.1093/intimm/dxq087

1460-2377

Sayaka Oki, Ben J. E. Raveney, C. Klemann, Takashi Yamamura, Xiaoli Li, Yu⁃chao DOU, Yueyan Liu, Chengchao Shi, Lili Cao, X. Q. Zhang, Rui Duan, Alessandro S. Farias, Rafael L. Talaisys, Yara C. Blanco, S. R. Lopes, A. F. Longhini, Leonilda Maria Barbosa dos Santos, Fábio Trindade Maranhão Costa, Shuai Chen, Yan Wang, Huey‐Kang Sytwu, Mahdia Benkhoucha, Marie‐Laure Santiago‐Raber, Michel Chofflon, Hiroshi Funakoshi, Takeshi Nakamura, Patrice H. Lalive, Izumi Kawachi, Kaori Yanagawa, E. Saji, M. Nishizawa, Tomonaga Matsushita, Motomu Tanaka, Noriko Isobe, Jun-ichi Kira, Nobuyuki Matsui, Shingo Nakane, Yousuke Takahama, Takahiro Maruta, H. Yoshikawa, María del Carmen García, Esther Moga, Estebán Martínez, Luís Querol, C. Juárez, Isabel Illa, Lirong Hong, Aline L. Noçon, Jacque Pak Kan Ip, Sue Ling Lim, Iain L. Campbell, Carolina Prado, Magaly J. Barrientos, Pablo Díaz, Héctor González, Rodrigo Pacheco, Pascale Giraudon, Michel Varrin‐Doyer, André Nicolle, Romain Marignier, Sylvie Cavagna, Claire Benetollo, Hidemitsu Kitamura, Masaki Kobayashi, Tomoya Nishimura, Judith Szelényi, Krisztián Tárnok, Klára Barabás, I. Székács, E. Madarász, Silvia Izquierdo Álvarez, A. Blanco, M. Fresno, María Ángeles Muñoz‐Fernández, Yan Ge, Xiao Dan Zhang, Kunikazu Tanji, Huanshui Zhang, Kuninobu Wakabayashi, N. Hsu, Philippa Randall, Boipelo Sebesho, Nasiema Allie, Lauriston Kellaway, Muazzam Jacobs, Aneta Sokal, W. Kuehnel, Vassily Roudenok, X. Shi, Danping Liu, Hao Duan, Lai Qian, Nan Guo, Jonathan I. Silverberg, David Ginsburg, Rena Orman, Mark G. Stewart, Vahé E. Amassian, Helen G. Durkin, Kathleen Vrolix, Judith Fraussen, Joke Van Den Broeck, Els V. Meulemans, Veerle Somers, Mario Losen, Marc H. De Baets, Pilar Martínez‐Martínez, Vuslat Yılmaz, Piraye Oflazer, Fikret Aysal, Yeşim Parman, Haner Di̇reskeneli̇, Feza Deymeer, Güher Saruhan‐Direskeneli, Or Cohen‐Inbar, Inbal Zafir‐Lavie, Menashe Zaaroor, Yoram Reiter, Tin-Tin-Win Shwe, Naoki Kunugita, Yasuhiro Yoshida, Keiichi Arashidani, Hidekazu Fujimaki, Paola Lanuti, Raskit Lachmann, Naji Tabet, Sebastianó Miscia, F. Kern, Nemesio Cedeño, M. Ferbabdez-Mestre, V. Obando, Antonio González de León, Gustavo Ramírez-González, José E. Rodríguez‐Borges, Félix Hernández, Ilva Campagna, Sofia Sequeira Crespo, Z. Layrisse, Ming H. Hsieh, Wooin Lee, H. Wang, Kátia Lin, Patrick C. K. Hung, Ming‐Yi Chou, Min Chang, Jinjin Huang, Hajime Sakuma, K Sugai, Masako Sasaki, Yao Gao, T. Mardovina, Zhuo Yu, Chiaki Ono, Y. Tanabe, Ichiro Sora, Saiko Aiba, Hiroshi Tomita, Marta Kubera, Almudena Gómez-Román, Jan Detka, Agnieszka Basta‐Kaim, Bogusława Budziszewska, M. Leskiewicz, P. Gruca, Barbara Korzeniak, Magdalena Regulska, Beata Grygier, Justyna Kuśmierczyk, Władysław Lasoń, Yu. I. Shilov, D. J. Shilov, С. Н. Шилов, E. V. Yurkova, Naoto Ishii, Q Coquerel, Maria Hamze Sinno, Jean‐Claude do Rego, H. B. Schiöth, Pierre Déchelotte, Sergueı̈ O. Fetissov, Varda Mehrotra, Vikramjit Lahiri,

Immune responses and vaccinations

and production of complement is increased following brain injury and neurodegeneration.Here, we discovered that complement receptor 2 (Cr2, also known as CD21/ CD35) is functionally expressed on neural progenitor cells (NPCs) and regulates their proliferation and responses to injury.By stereological quantification, we found that Cr2 knockout mice have significantly increased neurogenesis with more than 3-fold increase in DCX+ cells in the hippocampus of 20-months old Cr2 knockout mice.Additionally, we found that stimulation of NPCs with two ligands of Cr2, complement C3d and interferon-alpha (IFNa), reduced proliferation and neurosphere formation in vitro; this was restored by treatment with Cr2 neutralizing antibody.Corroborating these findings, we found that intracerebral injection of Cr2 ligands into the left hippocampus of wild type mice resulted in an average 35% decrease of BrdU + DCX+ cells in the ipsilateral compared with the saline injected side.Moreover, injection of C3d had no effect in Cr2 knockout mice.In conclusion, we provide evidence for a role of complement receptor 2 in regulating adult neurogenesis in the mouse hippocampus and postulate that the Cr2-mediated regulation of NPCs may mechanistically contribute to maintaining a neurogenic niche.