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Acupuncture for migraine prophylaxis: a randomized controlled trial

2012; Canadian Medical Association; Volume: 184; Issue: 4 Linguagem: Inglês

10.1503/cmaj.110551

1488-2329

Ying Li, Hui Zheng, Claudia M. Witt, Stephanie Roll, Shuguang Yu, Jie Yan, Guojie Sun, Ling Zhao, Wenjing Huang, Xiao-Rong Chang, Hongxing Zhang, Dejun Wang, Lei Lan, Ran Zou, Fanrong Liang,

Psychosomatic Disorders and Their Treatments

Acupuncture is commonly used to treat migraine. We assessed the efficacy of acupuncture at migraine-specific acupuncture points compared with other acupuncture points and sham acupuncture.We performed a multicentre, single-blind randomized controlled trial. In total, 480 patients with migraine were randomly assigned to one of four groups (Shaoyang-specific acupuncture, Shaoyang-nonspecific acupuncture, Yangming-specific acupuncture or sham acupuncture [control]). All groups received 20 treatments, which included electrical stimulation, over a period of four weeks. The primary outcome was the number of days with a migraine experienced during weeks 5-8 after randomization. Our secondary outcomes included the frequency of migraine attack, migraine intensity and migraine-specific quality of life.Compared with patients in the control group, patients in the acupuncture groups reported fewer days with a migraine during weeks 5-8, however the differences between treatments were not significant (p > 0.05). There was a significant reduction in the number of days with a migraine during weeks 13-16 in all acupuncture groups compared with control (Shaoyang-specific acupuncture v. control: difference -1.06 [95% confidence interval (CI) -1.77 to -0.5], p = 0.003; Shaoyang-nonspecific acupuncture v. control: difference -1.22 [95% CI -1.92 to -0.52], p < 0.001; Yangming-specific acupuncture v. control: difference -0.91 [95% CI -1.61 to -0.21], p = 0.011). We found that there was a significant, but not clinically relevant, benefit for almost all secondary outcomes in the three acupuncture groups compared with the control group. We found no relevant differences between the three acupuncture groups.Acupuncture tested appeared to have a clinically minor effect on migraine prophylaxis compared with sham acupuncture.Clinicaltrials.gov NCT00599586.