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Association of genetic variants in the adiponectin encoding gene (ADIPOQ) with type 2 diabetes in Japanese Brazilians

2009; Elsevier BV; Volume: 24; Issue: 2 Linguagem: Inglês

10.1016/j.jdiacomp.2009.01.007

1873-460X

Marcio Faleiros Vendramini, Alexandre C. Pereira, Sandra Roberta G. Ferreira, Teresa S. Kasamatsu, Regina S. Moisés,

Regulation of Appetite and Obesity

The objective of this study is to assess the contribution of ADIPOQ variants to type 2 diabetes in Japanese Brazilians.We genotyped 200 patients with diabetes mellitus (100 male and 100 female, aged 55.0 years [47.5-64.0 years]) and 200 control subjects with normal glucose tolerant (NGT) (72 male and 128 female, aged 52.0 years [43.5-64.5 years]).Whereas each polymorphism studied (T45G, G276T, and A349G) was not significantly associated with type 2 diabetes mellitus, the haplotype GGA was overrepresented in our diabetic population (9.3% against 3.1% in NGT individuals, P=.0003). Also, this haplotype was associated with decreased levels of adiponectin. We also identified three mutations in exon 3: I164T, R221S, and H241P, but, owing to the low frequencies of them, associations with type 2 diabetes could not be evaluated. The subjects carrying the R221S mutation had plasma adiponectin levels lower than those without the mutation (2.10 microg/ml [1.35-2.55 microg/ml] vs. 6.68 microg/ml [3.90-11.23 microg/ml], P=.015). Similarly, the I164T mutation carriers had mean plasma adiponectin levels lower than those noncarriers (3.73 microg/ml [3.10-4.35 microg/ml] vs. 6.68 microg/ml [3.90-11.23 microg/ml]), but this difference was not significant (P=.17).We identified in the ADIPOQ gene a risk haplotype for type 2 diabetes in the Japanese Brazilian population.