Cytologic diagnosis of brain metastasis from hepatocellular carcinoma by squash preparation
2006; Wiley; Volume: 34; Issue: 3 Linguagem: Inglês
10.1002/dc.20420
ISSN8755-1039
AutoresTadao K. Kobayashi, Masamichi Bamba, Masami Ueda, Toshihiro Nishino, Mitsue Muramatsu, Suzuko Moritani, Tetsuya Katsumori, Hideki Oka, Akihiko Hino, Masato Fujimoto, Ryoji Kushima,
Tópico(s)Radiopharmaceutical Chemistry and Applications
ResumoDiagnostic CytopathologyVolume 34, Issue 3 p. 227-231 Brief Report Cytologic diagnosis of brain metastasis from hepatocellular carcinoma by squash preparation Tadao K. Kobayashi Ph.D., C.F.I.A.C., Corresponding Author Tadao K. Kobayashi Ph.D., C.F.I.A.C. kobayashi@msn.com Department of Pathology, Saiseikai Shiga Hospital, Imperial Gift Foundation Inc., Ritto, Shiga, JapanDepartment of Pathology, Saiseikai Shiga Hospital, Imperial Gift Foundation Inc., 2-4-1 Oh-Hashi, Ritto, Shiga 520-3046, JapanSearch for more papers by this authorMasamichi Bamba M.D., Ph.D., Masamichi Bamba M.D., Ph.D. Department of Pathology, Saiseikai Shiga Hospital, Imperial Gift Foundation Inc., Ritto, Shiga, JapanSearch for more papers by this authorMasami Ueda C.T. (IAC), Masami Ueda C.T. (IAC) Department of Pathology, Saiseikai Shiga Hospital, Imperial Gift Foundation Inc., Ritto, Shiga, JapanSearch for more papers by this authorToshihiro Nishino C.T. (IAC), Toshihiro Nishino C.T. (IAC) Department of Pathology, Saiseikai Shiga Hospital, Imperial Gift Foundation Inc., Ritto, Shiga, JapanSearch for more papers by this authorMitsue Muramatsu C.T. (IAC), Mitsue Muramatsu C.T. (IAC) Department of Pathology, Saiseikai Shiga Hospital, Imperial Gift Foundation Inc., Ritto, Shiga, JapanSearch for more papers by this authorSuzuko Moritani M.D., Ph.D., Suzuko Moritani M.D., Ph.D. Department of Pathology, Nagoya Medical Center, Nagoya, Aichi, JapanSearch for more papers by this authorTetsuya Katsumori M.D., Ph.D., Tetsuya Katsumori M.D., Ph.D. Department of Radiology, Saiseikai Shiga Hospital, Imperial Gift Foundation Inc., Ritto, Shiga, JapanSearch for more papers by this authorHideki Oka M.D., Ph.D., Hideki Oka M.D., Ph.D. Department of Neurosurgery, Saiseikai Shiga Hospital, Imperial Gift Foundation Inc., Ritto, Shiga, JapanSearch for more papers by this authorAkihiko Hino M.D., Ph.D., Akihiko Hino M.D., Ph.D. Department of Neurosurgery, Saiseikai Shiga Hospital, Imperial Gift Foundation Inc., Ritto, Shiga, JapanSearch for more papers by this authorMasato Fujimoto M.D., Ph.D., Masato Fujimoto M.D., Ph.D. Department of Neurosurgery, Saiseikai Shiga Hospital, Imperial Gift Foundation Inc., Ritto, Shiga, JapanSearch for more papers by this authorRyoji Kushima M.D., Ph.D., Ryoji Kushima M.D., Ph.D. Division of Diagnostic Pathology, Shiga University of Medical Science, Ohtsu, Shiga, JapanSearch for more papers by this author Tadao K. Kobayashi Ph.D., C.F.I.A.C., Corresponding Author Tadao K. Kobayashi Ph.D., C.F.I.A.C. kobayashi@msn.com Department of Pathology, Saiseikai Shiga Hospital, Imperial Gift Foundation Inc., Ritto, Shiga, JapanDepartment of Pathology, Saiseikai Shiga Hospital, Imperial Gift Foundation Inc., 2-4-1 Oh-Hashi, Ritto, Shiga 520-3046, JapanSearch for more papers by this authorMasamichi Bamba M.D., Ph.D., Masamichi Bamba M.D., Ph.D. Department of Pathology, Saiseikai Shiga Hospital, Imperial Gift Foundation Inc., Ritto, Shiga, JapanSearch for more papers by this authorMasami Ueda C.T. (IAC), Masami Ueda C.T. (IAC) Department of Pathology, Saiseikai Shiga Hospital, Imperial Gift Foundation Inc., Ritto, Shiga, JapanSearch for more papers by this authorToshihiro Nishino C.T. (IAC), Toshihiro Nishino C.T. (IAC) Department of Pathology, Saiseikai Shiga Hospital, Imperial Gift Foundation Inc., Ritto, Shiga, JapanSearch for more papers by this authorMitsue Muramatsu C.T. (IAC), Mitsue Muramatsu C.T. (IAC) Department of Pathology, Saiseikai Shiga Hospital, Imperial Gift Foundation Inc., Ritto, Shiga, JapanSearch for more papers by this authorSuzuko Moritani M.D., Ph.D., Suzuko Moritani M.D., Ph.D. Department of Pathology, Nagoya Medical Center, Nagoya, Aichi, JapanSearch for more papers by this authorTetsuya Katsumori M.D., Ph.D., Tetsuya Katsumori M.D., Ph.D. Department of Radiology, Saiseikai Shiga Hospital, Imperial Gift Foundation Inc., Ritto, Shiga, JapanSearch for more papers by this authorHideki Oka M.D., Ph.D., Hideki Oka M.D., Ph.D. Department of Neurosurgery, Saiseikai Shiga Hospital, Imperial Gift Foundation Inc., Ritto, Shiga, JapanSearch for more papers by this authorAkihiko Hino M.D., Ph.D., Akihiko Hino M.D., Ph.D. Department of Neurosurgery, Saiseikai Shiga Hospital, Imperial Gift Foundation Inc., Ritto, Shiga, JapanSearch for more papers by this authorMasato Fujimoto M.D., Ph.D., Masato Fujimoto M.D., Ph.D. Department of Neurosurgery, Saiseikai Shiga Hospital, Imperial Gift Foundation Inc., Ritto, Shiga, JapanSearch for more papers by this authorRyoji Kushima M.D., Ph.D., Ryoji Kushima M.D., Ph.D. Division of Diagnostic Pathology, Shiga University of Medical Science, Ohtsu, Shiga, JapanSearch for more papers by this author First published: 09 February 2006 https://doi.org/10.1002/dc.20420Citations: 3AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinked InRedditWechat Abstract Hepatocellular carcinoma (HCC) metastasizes to the brain is rare instances. In published series and case reports of metastatic HCC, diagnosis of central nervous system metastases has been determined by histologic methods. We present a case of metastatic HCC of brain diagnosed by squash cytologic preparation. A 69-year-old male, HCV positive, suffering from post-hepatitic cirrhosis, initially diagnosed at age 68 with HCC presented with headaches of increasing frequency and severity. A computed tomography scan confirmed a 3-cm nodule in the right parietal lobe of the brain. Squash cytology was performed intraoperatively and preparations of a small tissue fragment resected from the mass showed medium-to-large-sized, well-cohesive clusters or sheets of uniform tumor cells. The tumor cells are highly cellular and contain solitary tumor cells in loose groupings as well as many fragments. They also appear somewhat bizarre and contain large, round, or ovoid nuclei with prominent nucleoli. Cytologic diagnosis of metastatic HCC was rendered reported and confirmed by a subsequent frozen section examination. To the best of our knowledge, this is the first reported case in which HCC was reported as brain metastasis, by using squash cytology. We suggest that intraoperative squash cytologic examination be viewed as a useful initial approach in the diagnosis of metastatic brain tumor. Diagn. Cytopathol. 2006;34: 227–231. © 2006 Wiley-Liss, Inc. Citing Literature Volume34, Issue3March 2006Pages 227-231 RelatedInformation
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