Portal de Periódicos da CAPES

Thiazide Diuretics Exacerbate Fructose-Induced Metabolic Syndrome

2007; American Society of Nephrology; Volume: 18; Issue: 10 Linguagem: Inglês

10.1681/asn.2007040416

1533-3450

Sirirat Reungjui, Carmen Roncal, Wei Mu, Titte R. Srinivas, Dhavee Sirivongs, Richard J. Johnson, Takahiko Nakagawa,

Alcohol Consumption and Health Effects

Fructose is a commonly used sweetener associated with diets that increase the prevalence of metabolic syndrome. Thiazide diuretics are frequently used in these patients for treatment of hypertension, but they also exacerbate metabolic syndrome. Rats on high-fructose diets that are given thiazides exhibit potassium depletion and hyperuricemia. Potassium supplementation improves their insulin resistance and hypertension, whereas allopurinol reduces serum levels of uric acid and ameliorates hypertension, hypertriglyceridemia, hyperglycemia, and insulin resistance. Both potassium supplementation and treatment with allopurinol also increase urinary nitric oxide excretion. We suggest that potassium depletion and hyperuricemia in rats exacerbates endothelial dysfunction and lowers the bioavailability of nitric oxide, which blocks insulin activity and causes insulin resistance during thiazide usage. Addition of potassium supplements and allopurinol with thiazides might be helpful in the management of metabolic syndrome.