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BIBTEX RIS

PhoP Can Activate Its Target Genes in a PhoQ-Independent Manner

2004; American Society for Microbiology; Volume: 186; Issue: 8 Linguagem: Inglês

10.1128/jb.186.8.2476-2480.2004

ISSN

1098-5530

Autores

Sergio Lejona, María Eugenia Castelli, María Laura Cabeza, Linda J. Kenney, Eleonora Garcı́a Véscovi, Fernando C. Soncini,

Tópico(s)

Iron Metabolism and Disorders

Resumo

ABSTRACT The PhoP/PhoQ two-component system controls the extracellular magnesium depletion response in Salmonella enterica . Previous studies have shown that PhoP is unable to up-regulate its target genes in the absence of PhoQ function. In this work, we demonstrate that PhoP overexpression can substitute for PhoQ- and phosphorylation-dependent activation. Either a high concentration of PhoP or activation via phosphorylation stimulates PhoP self-association.

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