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Mayores niveles de ECA y Angiotensina II determinados genéticamente, se asocian a menor actividad del eje ECA2/angiotensina-(1-9) y mayor remodelamiento de la pared aórtica de ratas hipertensas

2012; SciELO; Volume: 31; Issue: 2 Linguagem: Inglês

10.4067/s0718-85602012000200006

0718-8560

Jackeline Moya, Ulises Novoa, Nicolás Escudero, Iván Godoy, Mario Chiong, Sergio Lavandero, Jorge Jalil, María Paz Ocaranza,

Cardiovascular, Neuropeptides, and Oxidative Stress Research

Objective:To determine the effects of ACE gene polymorphism in the ECA2/Ang1-9 axis activity and its impact on the aortic wall remodeling secondary to hypertension (HT). Methods:Male homozygous rats BN and LL were used.Hypertension was induced by the Goldblatt procedure (GB, 2 K-1clip).Pseudo-operated rats were used as controls (Sham).At 6 weeks after surgery, we determined the body weight (BW) and systolic blood pressure (SBP).In aorta, we determined the ACE and ACE2 activities, Ang II/Ang1-9 levels, protein expression of collagen type I, positive cells for ED-1 inflammatory cells and medial thickness (MT) and area (MA) of aortic wall.Results: ACE polymorphism with higher levels of ACE and Ang II determined a significant decrease of ACE2 activity, Ang-(1-9) levels and aortic wall remodeling in normotensives and hypertensives rats. Conclusion: ACE polymorphism with increasedACE activity and AngII levels determines a significant inter-regulation between ACE/AngII and ACE2/Ang-(1-9) axis which is associated with increased remodeling of the aortic wall.Fondecyt 1100874.