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Examination of Biologically Active Nanocomplexes by Nanoparticle Tracking Analysis

2013; Oxford University Press; Volume: 19; Issue: 4 Linguagem: Inglês

10.1017/s1431927613000597

1435-8115

Nikolai A. Nikitin, Е.А. Трифонова, О. В. Карпова, J.G. Atabekov,

Bacteriophages and microbial interactions

Abstract Nanoparticle tracking analysis (NTA) was first applied to biologically active nanocomplexes to obtain concurrent information on their size, state of aggregation, concentration, and antigenic specificity in liquid. The subject of the NTA was an immunogenic complex (a candidate nanovaccine) comprised of spherical particles (SPs) generated by thermal remodeling of the tobacco mosaic virus and Rubella virus tetraepitopes exposed on the surface of SP.