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Donor Characteristics Affecting Graft Failure, Graft-versus-Host Disease, and Survival after Unrelated Donor Transplantation with Reduced-Intensity Conditioning for Hematologic Malignancies

2011; Elsevier BV; Volume: 17; Issue: 12 Linguagem: Inglês

10.1016/j.bbmt.2011.07.008

1523-6536

Jakob Passweg, Mei-Jie Zhang, Vanderson Rocha, Fangyu Kan, Richard E. Champlin, Luis Isola, Adrian P. Gee, John Gibson, Mary J. Laughlin, Hillard M. Lazarus, Alison W. Loren, David I. Marks, Aloïs Gratwohl, Mary Eapen,

Renal Transplantation Outcomes and Treatments

We examined the effect of donor characteristics on graft failure ( 95% donor chimerism, 145 patients were 5% to 95%, and 63 patients were <5%. The only donor characteristic associated with transplantation outcome was donor-recipient HLA matching. One- or 2-loci mismatched transplants led to higher grade 2-4 (relative risk [RR] = 1.27, P = .035) and grade 3-4 (RR = 1.85, P < .001) aGVHD and 2-loci mismatched transplants higher mortality (RR = 2.22, P < .001). Graft failure was higher after transplantation of bone marrow (RR = 2.33, P = .002). Donor age, parity, and donor sex match were not associated with transplantation outcome. Donor-recipient HLA matching is the only donor characteristic predictive for survival after RIC regimens for hematologic malignancies.