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Long-Term Outcome of Biopsy-Proven, Frequently Relapsing Minimal-Change Nephrotic Syndrome in Children

2009; Lippincott Williams & Wilkins; Volume: 4; Issue: 10 Linguagem: Inglês

10.2215/cjn.05691108

1555-905X

Henriette A.C. Kyrieleis, Marije M. Löwik, Ilse Pronk, Hans R.M. Cruysberg, Jan A.M. Kremer, Wim J.G. Oyen, Bert L. P. van den Heuvel, Jack F.M. Wetzels, Elena Levtchenko,

Renal cell carcinoma treatment

Frequently relapsing and steroid-dependent minimal-change nephrotic syndrome (MCNS) that originates in childhood can persist after puberty in >20% of patients. These patients require immunosuppressive treatment during several decades of their life. We examined long-term adverse effects of persistent nephrotic syndrome and immunosuppressive medications, focusing on renal function, growth, obesity, osteoporosis, hypertension, ocular complications, and fertility in adult patients with biopsy-proven childhood-onset MCNS. Molecular analysis was performed to evaluate a possible association of a complicated course of MCNS with podocyte gene mutations.