Effects of a serotonin 5-HT4 receptor antagonist SB-207266 on gastrointestinal motor and sensory function in humans
2000; BMJ; Volume: 47; Issue: 5 Linguagem: Inglês
10.1136/gut.47.5.667
ISSN1468-3288
Autores Tópico(s)Gastroesophageal reflux and treatments
ResumoBACKGROUND Serotonin 5-HT 4 receptors are located on enteric cholinergic neurones and may regulate peristalsis. 5-HT 4 receptors on primary afferent neurones have been postulated to modulate visceral sensation. While 5-HT 4 agonists are used as prokinetic agents, the physiological role of 5-HT 4 receptors in the human gut is unknown. AIMS Our aim was to characterise the role of 5-HT 4 receptors in regulating gastrointestinal motor and sensory function in healthy subjects under baseline and stimulated conditions with a 5-HT 4 receptor antagonist. METHODS Part A compared the effects of placebo to four doses of a 5-HT 4 receptor antagonist (SB-207266) on the cisapride mediated increase in plasma aldosterone (a 5-HT 4 mediated response) and orocaecal transit in 18 subjects. In part B, 52 healthy subjects received placebo, or 0.05, 0.5, or 5 mg of SB-207266 for 10–12 days; gastric, small bowel, and colonic transit were measured by scintigraphy on days 7–9, and fasting and postprandial colonic motor function, compliance, and sensation during distensions were assessed on day 12. RESULTS Part A: 0.5, 5, and 20 mg doses of SB-207266 had significant and quantitatively similar effects, antagonising the cisapride mediated increase in plasma aldosterone and acceleration of orocaecal transit. Part B: SB-207266 tended to delay colonic transit (geometric centre of isotope at 24 (p=0.06) and 48 hours (p=0.08)), but did not have dose related effects on transit, fasting or postprandial colonic motor activity, compliance, or sensation. CONCLUSION 5-HT 4 receptors are involved in the regulation of cisapride stimulated orocaecal transit; SB 207266 tends to modulate colonic transit but not sensory functions or compliance in healthy human subjects.
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