Portal de Periódicos da CAPES

Artigo Acesso aberto Produção Nacional Revisado por pares

BIBTEX RIS

In Vitro Antioxidant and Cytotoxic Activity of Some Synthetic Riparin-Derived Compounds

2014; Multidisciplinary Digital Publishing Institute; Volume: 19; Issue: 4 Linguagem: Inglês

10.3390/molecules19044595

1433-1373

Geandra Batista Lima Nunes, Paola Policarpo, Luciana Muratori Costa, Teresinha da Silva, Gardênia Carmen Gadelha Militão, Celso A. Câmara, José Maria Barbosa‐Filho, Stanley Juan Chavéz Gutierrez, Muhammad Torequl Islam, Rivelilson De Freitas,

Phytochemistry Medicinal Plant Applications

This study aimed to study the in vitro antioxidant activity and cytotoxicity on tumor cells lines of six synthetic substances derived from riparins. All the substances showed antioxidant activity and riparins C, D, E, F presented cell growth inhibition rates greater than 70%, suggesting that these molecules have antitumor properties. These substances also caused greater than 80% releases of cytoplasmic lactate dehydrogenase enzyme (LDH). Although the antioxidant and antitumor properties presented herein require further assessment, the outcomes indicate that these novel riparins are promising biologically active compounds.