Portal de Periódicos da CAPES

Suggestive evidence for linkage of schizophrenia to markers at chromosome 15q13–14 in Taiwanese families

2001; Wiley; Volume: 105; Issue: 8 Linguagem: Inglês

10.1002/ajmg.1547

1096-8628

Chih‐Min Liu, Hai‐Gwo Hwu, Ming‐Wei Lin, Wen‐Chen Ouyang, Sandy F.‐C. Lee, Cathy S.J. Fann, Su‐Hsien Wong, Shu‐Hua Hsieh,

Autism Spectrum Disorder Research

In order to evaluate the linkage of schizophrenia to loci at chromosome 15q, we genotyped six microsatellite markers at chromosome 15q11-14 in 52 Taiwanese schizophrenic families. Two phenotype models (narrow: DSM-IV schizophrenia only; and broad: including schizophrenia, schizoaffective, and other nonaffective psychotic disorders) were used to define the disease phenotype. Maximum nonparametric linkage scores (NPL scores) of 3.33 (P = 0.0003) and 2.96 (P = 0.0008) were obtained at the marker D15S976 under broad and narrow models, respectively. Positive linkage results were also observed at the marker D15S1360, previously reported to have significant linkage to a neurophysiological deficit of schizophrenia, with NPL scores of 2.71 (P = 0.003) and 2.78 (P = 0.002) under broad and narrow models, respectively. The results provide suggestive linkage evidence of schizophrenia to loci at chromosome 15q13-14 in an ethnically distinct Taiwanese sample.