No cytogenetic effects of quinolone treatment in humans
1988; American Society for Microbiology; Volume: 32; Issue: 6 Linguagem: Inglês
10.1128/aac.32.6.936
ISSN1098-6596
AutoresFelix Mitelman, Anne-Marie Kolnig, Bodil Strömbeck, Ragnar Norrby, Bjarne Kromann‐Andersen, Peter Sommer, Jan Wadstein,
Tópico(s)Drug Transport and Resistance Mechanisms
ResumoCytogenetic effects of ciprofloxacin (500 to 2,000 mg daily) and ofloxacin (200 mg daily) were studied in lymphocytes from 31 patients treated for 1 to 10 weeks. Blood samples for cytogenetic analysis were taken before the start of treatment from all patients, after 1 week from 25 patients, and after 2, 4, 6, and 10 weeks from six patients. No chromosome-damaging effect could be demonstrated in any treatment group. The mean aberration yields for each cytogenetic parameter studied and the total number of aberrations were all normal at each sampling occasion.
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