Portal de Periódicos da CAPES

Influence of the JAK2 V617F mutation and inherited thrombophilia on the thrombotic risk among patients with essential thrombocythemia

2009; Ferrata Storti Foundation; Volume: 94; Issue: 5 Linguagem: Inglês

10.3324/haematol.13869

1592-8721

Valerio De Stefano, Tommaso Zà, E. Rossi, Alessia Fiorini, Angela Ciminello, C. Luzzi, Patrizia Chiusolo, Simona Sica, Giuseppe Leone,

Blood Coagulation and Thrombosis Mechanisms

It is uncertain whether the JAK2 V617F mutation increases the thrombotic risk in patients with essential thrombocythemia, and it is unknown whether inherited thrombophilia is an additive risk factor in mutated subjects. We studied 132 patients with essential thrombocythemia, 38 of them (29%) with a history of thrombosis. The JAK2 mutation was present in 83 (63%), and inherited thrombophilia in 7. The mutated patients 60 years, no increase in RR was associated with the JAK2 mutation. In conclusion, in the younger patients with ET the thrombotic risk is higher in the JAK2 V617F-mutated and is further increased by the presence of inherited thrombophilia.