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THE DIAGNOSIS OF INTERSTITIAL CYSTITIS REVISITED: LESSONS LEARNED FROM THE NATIONAL INSTITUTES OF HEALTH INTERSTITIAL CYSTITIS DATABASE STUDY

1999; Lippincott Williams & Wilkins; Volume: 161; Issue: 2 Linguagem: Inglês

10.1016/s0022-5347(01)61948-7

1527-3792

Philip M. Hanno, J. Richard Landis, Yvonne Matthews-Cook, John W. Kusek, Leroy Nyberg,

Urological Disorders and Treatments

No AccessJournal of UrologyClinical Urology: Female Urology1 Feb 1999THE DIAGNOSIS OF INTERSTITIAL CYSTITIS REVISITED: LESSONS LEARNED FROM THE NATIONAL INSTITUTES OF HEALTH INTERSTITIAL CYSTITIS DATABASE STUDY PHILIP M. HANNO, J. RICHARD LANDIS, YVONNE MATTHEWS-COOK, JOHN KUSEK, and LEROY JR. NYBERG PHILIP M. HANNOPHILIP M. HANNO , J. RICHARD LANDISJ. RICHARD LANDIS , YVONNE MATTHEWS-COOKYVONNE MATTHEWS-COOK , JOHN KUSEKJOHN KUSEK , and LEROY JR. NYBERGLEROY JR. NYBERG View All Author Informationhttps://doi.org/10.1016/S0022-5347(01)61948-7AboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract Purpose: The lack of a precise working definition of interstitial cystitis may have resulted in the de facto use of the National Institute of Diabetes, Digestive and Kidney Diseases (NIDDK) "research" definition by clinicians. We evaluated these strict criteria in light of the broader inclusion criteria for patients evaluated in the Interstitial Cystitis Database study to determine their utility in clinical practice as a useful basis for the diagnosis of interstitial cystitis. Materials and Methods: A total of 379 women who completed screening for the Interstitial Cystitis Database before January 1, 1996 met the basic criteria of urinary frequency, urgency or pain for at least 6 months in duration without a diagnosable etiology. Of these patients 148 underwent cystoscopy and hydrodistention of the bladder as a part of the evaluation. All patients were followed for a minimum of 1 year. Comparisons were made between patients judged to have a clinical diagnosis of interstitial cystitis and those who met the NIDDK research definition of the syndrome. Results: Almost 90% of patients potentially meeting NIDDK criteria are believed by experienced clinicians to have interstitial cystitis, confirming the research value of these criteria in defining a homogeneous population for study. However, strict application of NIDDK criteria would have misdiagnosed more than 60% of patients regarded by researchers as definitely or likely to have interstitial cystitis. Conclusions: The NIDDK criteria are too restrictive to be used by clinicians as the diagnostic definition of interstitial cystitis. References 1 : Interstitial cystitis: a critique of current concepts with a new proposal for pathologic diagnosis and pathogenesis. Urology1997; 49: 14. Google Scholar 2 : Mast cells and nerve fibers in interstitial cystitis (IC): an algorithm for histologic diagnosis via quantitative image analysis and morphometry (QIAM). Urology1997; 49: 41. Google Scholar 3 : The pathology of interstitial cystitis. In: Interstitial Cystitis. Edited by . 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Link, Google Scholar THE INTERSTITIAL CYSTITIS DATABASE STUDY GROUP; From the University of Pennsylvania, Graduate Hospital and Temple University, Philadelphia, and Pennsylvania State University, Hershey, Pennsylvania, University of California at San Diego, San Diego, California, University of Oklahoma, Oklahoma City, Oklahoma, Northwestern University, Chicago, Illinois, University of Wisconsin at Madison, Madison, Wisconsin, William Beaumont Hospital, Royal Oak and Henry Ford Hospital, Detroit, Michigan, and National Institutes of Diabetes, Digestive and Kidney Diseases, Bethesda, MarylandSupported by National Institutes of Health Grant U01 DK45859.(HANNO) Requests for reprints: Department of Urology, 3 Parkinson Pavilion, Temple University Hospital, Broad and Tioga Sts., Philadelphia, Pennsylvania 19140.(HANNO) Current Address: Division of Reproductive and Urologic Drug Products, Food and Drug Administration, Rockville, Maryland 20854.© 1999 by American Urological Association, 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Volume 161Issue 2February 1999Page: 553-557 Advertisement Copyright & Permissions© 1999 by American Urological Association, Inc.MetricsAuthor Information PHILIP M. HANNO More articles by this author J. RICHARD LANDIS More articles by this author YVONNE MATTHEWS-COOK More articles by this author JOHN KUSEK More articles by this author LEROY JR. NYBERG More articles by this author Expand All Advertisement PDF downloadLoading ...