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Absorption of enrofloxacin and marbofloxacin after oral and subcutaneous administration in diseased koalas (Phascolarctos cinereus)

2010; Wiley; Volume: 33; Issue: 6 Linguagem: Inglês

10.1111/j.1365-2885.2010.01169.x

1365-2885

Joanna E. Griffith, Damien P. Higgins, Kong M. Li, Mark Krockenberger, Merran Govendir,

Blood groups and transfusion

Journal of Veterinary Pharmacology and TherapeuticsVolume 33, Issue 6 p. 595-604 Absorption of enrofloxacin and marbofloxacin after oral and subcutaneous administration in diseased koalas (Phascolarctos cinereus) J. E. GRIFFITH, J. E. GRIFFITH Faculty of Veterinary ScienceSearch for more papers by this authorD. P. HIGGINS, D. P. HIGGINS Faculty of Veterinary ScienceSearch for more papers by this authorK. M. LI, K. M. LI Sydney Medical School, The University of Sydney, Camperdown, NSW, AustraliaSearch for more papers by this authorM. B. KROCKENBERGER, M. B. KROCKENBERGER Faculty of Veterinary ScienceSearch for more papers by this authorM. GOVENDIR, M. GOVENDIR Faculty of Veterinary ScienceSearch for more papers by this author J. E. GRIFFITH, J. E. GRIFFITH Faculty of Veterinary ScienceSearch for more papers by this authorD. P. HIGGINS, D. P. HIGGINS Faculty of Veterinary ScienceSearch for more papers by this authorK. M. LI, K. M. LI Sydney Medical School, The University of Sydney, Camperdown, NSW, AustraliaSearch for more papers by this authorM. B. KROCKENBERGER, M. B. KROCKENBERGER Faculty of Veterinary ScienceSearch for more papers by this authorM. GOVENDIR, M. GOVENDIR Faculty of Veterinary ScienceSearch for more papers by this author First published: 09 November 2010 https://doi.org/10.1111/j.1365-2885.2010.01169.xCitations: 33 Joanna Elizabeth Griffith, Faculty of Veterinary Science;†Sydney Medical School, The University of Sydney, Camperdown, NSW 2006, Australia. E-mail: [email protected] Read the full textAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onEmailFacebookTwitterLinkedInRedditWechat Abstract Griffith, J.E., Higgins, D.P., Li, K.M., Krockenberger, M.B., Govendir, M. Absorption of enrofloxacin and marbofloxacin after oral and subcutaneous administration in diseased koalas (Phascolarctos cinereus). J. vet. Pharmacol. Therap. 33, 595–604. Koalas (n = 43) were treated daily for up to 8 weeks with enrofloxacin: 10 mg/kg subcutaneously (s.c.), 5 mg/kg s.c., or 20 mg/kg per os (p.o.); or marbofloxacin: 1.0–3.3 mg/kg p.o., 10 mg/kg p.o. or 5 mg/kg s.c. Serial plasma drug concentrations were determined on day 1 and again at approximately 2 weeks, by liquid chromatography. The median (range) plasma maximum concentrations (Cmax) for enrofloxacin 5 mg/kg s.c. and 10 mg/kg s.c. were 0.83 (0.68–1.52) and 2.08 (1.34–2.96) μg/mL and the median (range) Tmax were 1.5 h (1–2) and 1 h (1–2) respectively. Plasma concentrations of orally dosed marbofloxacin were too low to be quantified. Oral administration of enrofloxacin suggested absorption rate limited disposition pharmacokinetics; the median (range) Cmax for enrofloxacin 20 mg/kg p.o. was 0.94 (0.76–1.0) μg/mL and the median (range) Tmax was 4 h (2–8). Oral absorption of both drugs was poor. Plasma protein binding for enrofloxacin was 55.4 ± 1.9% and marbofloxacin 49.5 ± 5.3%. 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