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Self‐Assembly of a DNA Dodecahedron from 20 Trisoligonucleotides with C 3 h Linkers

2008; Wiley; Volume: 47; Issue: 19 Linguagem: Inglês

10.1002/anie.200702682

1521-3773

Jan Zimmermann, Martin P. J. Cebulla, Sven Mönninghoff, Günter von Kiedrowski,

RNA Interference and Gene Delivery

Can 20 trisoligonucleotides with 20×3 individual sequences be programmed to self-assemble into a DNA dodecahedron? The answer is yes if one starts from a new generation of trisoligonucleotides based on C3h-symmetric linkers with proper flexibility. The resulting dodecahedron has C1 symmetry and may facilitate the construction of multimodular scaffolds in the future. Supporting information for this article is available on the WWW under http://www.wiley-vch.de/contents/jc_2002/2008/z702682_s.pdf or from the author. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.