Portal de Periódicos da CAPES

Comparison of the contractile responses of human coronary bypass grafts and monkey arteries to human urotensin‐II

2001; Wiley; Volume: 15; Issue: 4 Linguagem: Inglês

10.1046/j.1472-8206.2001.00032.x

1472-8206

Jérôme Paysant, Alain Rupin, Serge Simonet, Jean‐Noël Fabiani, T.J. Verbeuren,

Thermal Expansion and Ionic Conductivity

Human urotensin‐II (hU‐II) is a cyclic peptide recently cloned in humans and present in human cardiac tissue and human arteries. The effects of hU‐II were studied on human coronary bypass grafts in vitro. In three out of eight human mammary arteries, and two out of three human radial arteries, hU‐II caused contraction; human saphenous veins did not respond to hU‐II. When it exists, the contraction slowly develops and has a low‐to‐moderate intensity. All radial arteries obtained from young healthy non‐human primates contracted strongly to hU‐II.