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Combination of liver biopsy with MELD-XI scores for post-transplant outcome prediction in patients with advanced heart failure and suspected liver dysfunction

2014; Elsevier BV; Volume: 34; Issue: 7 Linguagem: Inglês

10.1016/j.healun.2014.12.009

1557-3117

Maryjane Farr, James Mitchell, Matthew Lippel, Tomoko S. Kato, Zhezhen Jin, Paul Ippolito, Lorna Dove, Ulrich P. Jorde, Hiroo Takayama, Jean Emond, Yoshifumi Naka, Donna Mancini, Jay H. Lefkowitch, P. Christian Schulze,

Hepatitis C virus research

Functional and structural liver abnormalities may be found in patients with advanced heart failure (HF). The Model of End-Stage Liver Disease Excluding INR (MELD-XI) score allows functional risk stratification of HF patients on and off anti-coagulation awaiting heart transplantation (HTx), but these scores may improve or worsen depending on bridging therapies and during time on the waiting list. Liver biopsy is sometimes performed to assess for severity of fibrosis. Uncertainty remains whether biopsy in addition to MELD-XI improves prediction of adverse outcomes in patients evaluated for HTx.