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Method for Phenotypic Detection of Extended-Spectrum Beta-Lactamases in Enterobacter Species in the Routine Clinical Setting

2011; American Society for Microbiology; Volume: 49; Issue: 7 Linguagem: Inglês

10.1128/jcm.00864-11

1098-660X

James Cohen Stuart, B. M. W. Diederen, Nashwan al Naiemi, Ad C. Fluit, Niek Arents, Steven Thijsen, Bart J. M. Vlaminckx, Johan W. Mouton, Maurine Leverstein-Van Hall,

Antibiotic Use and Resistance

ABSTRACT In 271 Enterobacter blood culture isolates from 12 hospitals, extended-spectrum beta-lactamase (ESBL) prevalence varied between 0% and 30% per hospital. High prevalence was associated with dissemination, indicating the potential relevance of infection control measures. Screening with cefepime or Vitek 2, followed by a cefepime/cefepime-clavulanate Etest, was an accurate strategy for ESBL detection in Enterobacter isolates (positive predictive value, 100%; negative predictive value, 99%).