Enhancement of alkene reactivity by a trifluoromethyl group: Synthesis of pyrrolidines via 1,3-dipolar cycloaddition
1993; Elsevier BV; Volume: 34; Issue: 20 Linguagem: Inglês
10.1016/s0040-4039(00)73681-1
ISSN1873-3581
AutoresJean‐Pierre Bégué, Danièle Bonnet-Delpon aThierry Lequeux,
Tópico(s)Cyclopropane Reaction Mechanisms
ResumoEthylenic compounds activated by a trifluoromethyl group undergo 1,3-dipolar cycloaddinons with non stabilized azomethine ylides to provide polysubstituted 3-trifluoromethyl-pyrrolidines in while non-fluorinated parent alkenes are in most cases unreactive in these reactions.
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