Solid-phase synthesis of lysine-based cluster galactosides with high affinity for the asialoglycoprotein Receptor
1997; Elsevier BV; Volume: 53; Issue: 2 Linguagem: Inglês
10.1016/s0040-4020(96)01018-6
ISSN1464-5416
AutoresA. Rob P.M. Valentijn, Gijgs A. van der Marel, Leo A. J. M. Sliedregt, Theo J.C. van Berkel, Erik A.L. Biessen, Jacques H. van Boom,
Tópico(s)Chemical Synthesis and Analysis
ResumoStructurally well defined di- and tri-antennary lysine-based galactose- and N-acetylgalactosamine-containing ligands for the hepatic asialoglycoprotein receptor (ASGP-R) could be assembled on a solid support, using a combined Fmoc/Alloc protecting group strategy for the amino functions of lysine. This methodology allowed easy introduction of spacers, the length of which could be readily accommodated for optimal binding to the ASGP-R.
Referência(s)