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Induced pluripotent stem cells (iPSCs) and neurological disease modeling: progress and promises

2011; Oxford University Press; Volume: 20; Issue: R2 Linguagem: Inglês

10.1093/hmg/ddr336

1460-2083

Maria C. Marchetto, Kristen Brennand, Leah Boyer, Fred H. Gage,

Neuroscience and Neural Engineering

The systematic generation of neurons from patients with neurological disorders can provide important insights into disease pathology, progression and mechanism. This review will discuss recent progress in modeling neurodegenerative and neurodevelopmental diseases using induced pluripotent stem cells (iPSCs) and highlight some of the current challenges in the field. Combined with other technologies previously used to study brain disease, iPSC modeling has the promise to influence modern medicine on several fronts: early diagnosis, drug development and effective treatment.