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Emergence of Multiple Human Cytomegalovirus Ganciclovir-Resistant Mutants with Deletions and Substitutions within the UL97 Gene in a Patient with Severe Combined Immunodeficiency

2001; American Society for Microbiology; Volume: 45; Issue: 2 Linguagem: Inglês

10.1128/aac.45.2.593-595.2001

1098-6596

Dana G. Wolf, Isaac Yaniv, Shai Ashkenazi, Alik Honigman,

Immunodeficiency and Autoimmune Disorders

ABSTRACT Infection with multiple ganciclovir-resistant human cytomegalovirus mutants, containing different substitutions and deletions in the UL97 gene, was found in a patient with severe combined immunodeficiency (SCID) within 3 weeks of ganciclovir therapy. A novel 11-codon deletion at positions 590 to 600 was identified. These unique findings may be related to the nature of the immunodeficiency in the SCID patient.