Comparative hypoglycemic activity of different extracts of <i>Teucrium stocksianum</i> in diabetic rabbits
2013; Bangladesh Pharmacological Society; Volume: 8; Issue: 2 Linguagem: Inglês
10.3329/bjp.v8i2.14519
ISSN1991-0088
AutoresAlamgeer Umme Habiba Hasan, Imran Rashid, Sajid Bashir, Muhammad Naveed Mushtaq, Hafeez Ullah Khan, Muhammad Nasir Hayat Malik, Abdul Qayyum, Muhammad Rahaman,
Tópico(s)Liver Disease Diagnosis and Treatment
ResumoIn the present study crude powder and various extracts of Teucrium stocksianum were evaluated for antidiabetic effect in alloxan-induced diabetic rabbits. Crude extract significantly reduced blood glucose level of normal and diabetic rabbits. The results were comparable with standard drug gliben-clamide. Ethyl acetate extract (500 mg/kg) produced maximum decrease in blood glucose level among all the extracts and was selected for further study. Ethyl acetate extract significantly inhibited rise in glucose level in normal rabbits after an oral glucose load. The extract showed synergistic effect with different doses of insulin. Serum insulin level of diabetic rabbits was also significantly increased by the extract. HbA1c level was significantly (p<0.05) reduced whereas hemoglobin level was significantly increased by the extract. It is concluded that ethyl acetate extract may be a good remedy to manage diabetes and its complications.
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