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The discovery net system for high throughput bioinformatics

2003; Oxford University Press; Volume: 19; Issue: suppl_1 Linguagem: Inglês

10.1093/bioinformatics/btg1031

1367-4811

Anthony Rowe, Dimitrios Rafail Kalaitzopoulos, Michelle Osmond, Moustafa Ghanem, Yike Guo,

Bioinformatics and Genomic Networks

Abstract Motivation: Bioinformatics requires Grid technologies and protocols to build high performance applications without focusing on the low level detail of how the individual Grid components operate. Results: The Discovery Net system is a middleware that allows service developers to integrate tools based on existing and emerging Grid standards such as web services. Once integrated, these tools can be used to compose reusable workflows using these services that can later be deployed as new services for others to use. Using the Discovery Net system and a range of different bioinformatics tools, we built a Grid based application for Genome Annotation. This includes workflows for automatic nucleotide annotation, annotation of predicted proteins and text analysis based on metabolic profiles and text analysis. Contact: asr99@doc.ic.ac.uk Keywords: grid, E-Science, annotation, workflow, pipeline. *To whom correspondence should be addressed.