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Folarographic Behaviour of Nitrendipine

1988; Taylor & Francis; Volume: 21; Issue: 12 Linguagem: Inglês

10.1080/00032718808059910

1532-236X

J.A. Squella, Igor Lemus, Sara Perna, L. J. Nuñtez-Vergara,

Analytical Chemistry and Sensors

Abstract Nifedipine, a calcium antagonist drug, proceduces a well-defined polarographic wave due to the four-electron, four-proton reduction of the nitro group. This peak is diffusion-controlled and shows a linear dependence on the Nitrendipine concentration. This behaviour is used for analytical purposes in determining Nitrendipine content in commercial preparations. The method is sensitive enough to be applied to single tablet, assays. However, the principal advantage lies in the prompt determination. Preparation of the samples is easy and no extraction procedure is required. The method is recommended for uniformity contents studies and stability tests in day-to-day routine analyses.