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The DNA-dependent protein kinase

1999; Cold Spring Harbor Laboratory Press; Volume: 13; Issue: 8 Linguagem: Inglês

10.1101/gad.13.8.916

1549-5477

Graeme C.M. Smith, Stephen P. Jackson,

Genomics and Chromatin Dynamics

The DNA-dependent protein kinase (DNA–PK) is anuclear serine/threonine protein kinase that is activatedupon association with DNA. Biochemical and geneticdata have revealed DNA–PK to be composed of a largecatalytic subunit, termed DNA–PKcs, and a regulatoryfactor termed Ku. In recent years, mammalian DNA–PKhas been shown to be a crucial component of both theDNA double-strand break (DSB) repair machinery andthe