Population-based studies of myocardial hypertrophy: high resolution cardiovascular magnetic resonance atlases improve statistical power
2014; BioMed Central; Volume: 16; Issue: 1 Linguagem: Inglês
10.1186/1532-429x-16-16
ISSN1532-429X
AutoresAntonio de Marvao, Timothy J. W. Dawes, Wenzhe Shi, Christopher Minas, Niall Keenan, Tamara Diamond, Giuliana Durighel, Giovanni Montana, Daniel Rueckert, Stuart A. Cook, Declan P. O’Regan,
Tópico(s)Cardiac Imaging and Diagnostics
ResumoCardiac phenotypes, such as left ventricular (LV) mass, demonstrate high heritability although most genes associated with these complex traits remain unidentified. Genome-wide association studies (GWAS) have relied on conventional 2D cardiovascular magnetic resonance (CMR) as the gold-standard for phenotyping. However this technique is insensitive to the regional variations in wall thickness which are often associated with left ventricular hypertrophy and require large cohorts to reach significance. Here we test whether automated cardiac phenotyping using high spatial resolution CMR atlases can achieve improved precision for mapping wall thickness in healthy populations and whether smaller sample sizes are required compared to conventional methods.
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