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Efectividad de baclofeno en el tratamiento de espasticidad de origen cerebral

1996; Elsevier BV; Volume: 67; Issue: 5 Linguagem: Inglês

10.4067/s0370-41061996000500003

0717-6228

Isabel Lopez S, Monica Troncoso Sch, Maria de los Angeles Avaria B, Alvaro Clunes C, Marta Hernández,

Streptococcal Infections and Treatments

Baclofen in spastic cerebral palsyObjetives: to evaluate the effectiveness o r baclofen versus plccebo to "educe soas'iciy and improve molor ^notion, funct'oncl cutonomy, and self care.Design prospective two stages, 6-week each, baclofen I" to 2 tig • kg • cav) and placebo (-rvcrrre.37.5 mg • d; cross over administrct'on trial.Subjects: palients with spast'c cerebral palsy liv : ng in a charity institution for invalid youngsters under medicai cere of o university associated puolic general hospital pediat'ic neurology cl'n'c at rretropohan Santiago, Chile.Twenty persons ogee' 3 to 26 years with spastic cerebral pclsy.AAeasure-nents and results: weekly assessments of squeletal muscle tone with the Ashworth scale (scored • to 5 bcsa and 19/20 at placebo evaluations to ten oatients achieving score 2 under baclofen treatment [VVilcoxo" test p < C.051.Improvement in spontaneus mcvemeit and in routine cere management participation wcs observed in nine patients, No changes in motor function were reco'ded.Greater improvement was seen in patients with better "nteligence levels and less severe notcr disfunctb".Concbssion: baclofen should be considered a useful additional aid in the management of patients with spastic cereorcl palsy.Furher stucies shoud be done to assess long term effects of baclofen or t'-ese patients.