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Comparison of Imported Plasmodium ovale curtisi and P. ovale wallikeri Infections among Patients in Spain, 2005–2011

2014; Centers for Disease Control and Prevention; Volume: 20; Issue: 3 Linguagem: Inglês

10.3201/eid2003.130745

1080-6059

Gerardo Rojo-Marcos, José Miguel Rubio, Germán Ramírez‐Olivencia, Silvia García‐Bujalance, Rosa Elcuaz‐Romano, Marta Díaz‐Menéndez, María Calderón‐Moreno, Isabel García-Bermejo, José Manuel Ruiz‐Giardín, F. Merino, Diego Torrús, Alberto Delgado‐Iribarren, Mónica Ribell-Bachs, Juan Arévalo‐Serrano, Juan Cuadros‐González,

Venomous Animal Envenomation and Studies

Sequencing data from Plasmodium ovale genotypes co-circulating in multiple countries support the hypothesis that P. ovale curtisi and P. ovale wallikeri are 2 separate species. We conducted a multicenter, retrospective, comparative study in Spain of 21 patients who had imported P. ovale curtisi infections and 14 who had imported P. ovale wallikeri infections confirmed by PCR and gene sequencing during June 2005-December 2011. The only significant finding was more severe thrombocytopenia among patients with P. ovale wallikeri infection than among those with P. ovale curtisi infection (p = 0.031). However, we also found nonsignificant trends showing that patients with P. ovale wallikeri infection had shorter time from arrival in Spain to onset of symptoms, lower level of albumin, higher median maximum core temperature, and more markers of hemolysis than did those with P. ovale curtisi infection. Larger, prospective studies are needed to confirm these findings.