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Walking the walk: how kinesin and dynein coordinate their steps

2009; Elsevier BV; Volume: 21; Issue: 1 Linguagem: Inglês

10.1016/j.ceb.2008.12.002

1879-0410

Arne Gennerich, Ronald D. Vale,

Protist diversity and phylogeny

Molecular motors drive key biological processes such as cell division, intracellular organelle transport, and sperm propulsion and defects in motor function can give rise to various human diseases. Two dimeric microtubule-based motor proteins, kinesin-1 and cytoplasmic dynein can take over one hundred steps without detaching from the track. In this review, we discuss how these processive motors coordinate the activities of their two identical motor domains so that they can walk along microtubules.