Portal de Periódicos da CAPES

How protected are populations if transmission relapses? Insights from mathematical modeling and simulation

2012; BioMed Central; Volume: 11; Issue: S1 Linguagem: Inglês

10.1186/1475-2875-11-s1-o55

1475-2875

Cátia Bandeiras, M. Gabriela M. Gomes, Carlos Penha‐Gonçalves, Maria Jesus Trovoada, Lígia Antunes Gonçalves, Cláudio Romero Farias Marinho, Francisco Freixo, Lars Hviid, Louise Turner,

Parasites and Host Interactions

Background Malaria control measures have been successful in reducing malaria mortality and morbidity in sub-Saharan Africa in the last decade. In particular, in Principe Island, Sao Tome e Principe, after 5 years of control measures, Plasmodium falciparum incidence has decreased 99% and prevalence measured by slide-positivity rate was below 1% in 2009 [1]. However, this method lacks sensitivity for detection of asymptomatic and sub-patent parasite carriage that has implications on transmission [2]. Furthermore, control measures have the adverse effect of promoting decrease of immunity against the parasite, and a relapse in transmission might therefore have more severe consequences on infected individuals [3].