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Lack of an Effect of High Dose Isoflavones in Men With Prostate Cancer Undergoing Androgen Deprivation Therapy

2009; Lippincott Williams & Wilkins; Volume: 182; Issue: 5 Linguagem: Inglês

10.1016/j.juro.2009.07.030

1527-3792

Preetika Sharma, Amy B. Wisniewski, Milena Braga‐Basaria, Xiaoqiang Xu, Mary Yep, Samuel R. Denmeade, Adrian S. Dobs, Theodore L. DeWeese, Michael A. Carducci, Shehzad Basaria,

Menopause: Health Impacts and Treatments

The profound hypogonadism due to androgen deprivation therapy for prostate cancer results in complications such as sexual dysfunction, poor quality of life, vasomotor symptoms and altered cognition. Since estrogen is associated with cardiovascular risks, phytoestrogens are being increasingly evaluated as a potential treatment for these adverse effects. We evaluated the effects of high dose isoflavones, equivalent to that consumed by Asian populations, on the aforementioned consequences of androgen deprivation therapy.