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Reversible gonadotropin Deficiency in Male Cushing's Dusease

1977; Oxford University Press; Volume: 45; Issue: 3 Linguagem: Inglês

10.1210/jcem-45-3-488

1945-7197

Jean-Pierre Luton, P Thiéblot, J Valcke, J Mahoudeau, H Bricaire,

Growth Hormone and Insulin-like Growth Factors

Twelve adult males with documented active Cushing's disease were studied. Mean plasma testosterone (T) was significantly decreased: 1.8 +/- 0.3 (SEM) ng/ml (N=6.8 +/- 0.5); gonadotropin measurements in 8 patients, in basal conditions and under LH-RH iv, showed a significant decrease in both FSH and LH. A further study of 11 patients in remission of Cushing's disease indicated a significant increase in plasma T and gonadotropins up to the normal range. One patient with an initial low T value had a normalized T while in remission, then a dramatic decrease when the disease relapsed. We conclude: a hypogonadotropic hypogonadism is found in male Cushing's disease; it disappears as early as hypercortisolism is suppressed. Some possible mechanisms are discussed.