An Animal Model of MERS Produced by Infection of Rhesus Macaques With MERS Coronavirus
2013; Oxford University Press; Volume: 209; Issue: 2 Linguagem: Inglês
10.1093/infdis/jit590
ISSN1537-6613
AutoresYufeng Yao, Linlin Bao, Wei Deng, Lili Xu, Fang Li, Qi Lv, Pin Yü, Ting Chen, Yiyao Xu, Hua Zhu, Jing Yuan, Songzhi Gu, Wei Qin, Honglin Chen, Kwok‐Yung Yuen, Chuan Qin,
Tópico(s)Animal Virus Infections Studies
ResumoIn 2012, a novel coronavirus (CoV) associated with severe respiratory disease, Middle East respiratory syndrome (MERS-CoV; previously known as human coronavirus–Erasmus Medical Center or hCoV-EMC), emerged in the Arabian Peninsula. To date, 114 human cases of MERS-CoV have been reported, with 54 fatalities. Animal models for MERS-CoV infection of humans are needed to elucidate MERS pathogenesis and to develop vaccines and antivirals. In this study, we developed rhesus macaques as a model for MERS-CoV using intratracheal inoculation. The infected monkeys showed clinical signs of disease, virus replication, histological lesions, and neutralizing antibody production, indicating that this monkey model is suitable for studies of MERS-CoV infection.
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