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Chronic inflammatory disease, lymphoid tissue neogenesis and extranodal marginal zone B-cell lymphomas

2009; Ferrata Storti Foundation; Volume: 94; Issue: 8 Linguagem: Inglês

10.3324/haematol.2009.005983

1592-8721

Richard J. Bende, Febe van Maldegem, C. J. M. van Noesel,

Cancer Immunotherapy and Biomarkers

Chronic autoimmune or pathogen-induced immune reactions resulting in lymphoid neogenesis are associated with development of malignant lymphomas, mostly extranodal marginal zone B-cell lymphomas (MZBCLs). In this review we address (i) chemokines and adhesion molecules involved in lymphoid neogenesis; (ii) the autoimmune diseases and pathogens which are associated with development of B-cell lymphomas; (iii) the molecular mechanisms involved in the initiation and progression of MZBCL; and (iv) 'potential' mouse models for MZBCL.